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Dr Ian Geh's Published Studies List of Publications - The Birmingham Bowel Clinic
Browse by Genre Available eBooks Minakshi Bhardwaj , nursing tutor at college of nursing at college of nursing. Jeid Nazareno. Show More. No Downloads. Views Total views. Actions Shares. Embeds 0 No embeds. These therapeutic modalities are posterior sacral root neuromodulation, posterior tibial nerve stimulation, vanilloid agent intravesical instillation, intradetrusor botulinum toxin injections and surgery.
A certain efficiency of each of these treatments in the interstitial cystitis has been reported. However, the evaluation of these treatments is limited and the level of evidence is too low to propose these treatments in routine. We evaluate the efficacy of hyaluronate acid instillation for treatment of interstitial cystitis IC. From March to May , a prospective study included 31 patients.
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Patients have a urinalysis, a cystoscopy, a hydrodistension test and bladder biopsies. The urodynamic evaluation was not systematic. Patients received weekly six instillations of 40mg 50ml intravesical hyaluronate acid. Four groups were defined: good response, partial response, poor response and no response.
No serious side effects were observed. Hyaluronate acid has a place in the treatment of interstitial cystitis with an efficiency comparable to other treatments and good tolerance. The response rate to treatment can be improved by better selection of patients , particularly those having a cystoscopy and histology abnormal. All rights reserved. Bladder wall nitric oxide production in patients with bladder pain syndrome type 3C is increased compared to undetectable nitric oxide in patients with nonHunner bladder pain syndrome and healthy controls.
Cold cup biopsies from 7 patients with bladder pain syndrome type 3C and 6 healthy subjects were analyzed. IL protein expression was determined by immunohistochemistry. Mast cells were labeled with tryptase to evaluate cell appearance and count. ILA expression at the protein level was up-regulated and localized to inflammatory cells and urothelium in patients with bladder pain syndrome type 3C.
ILA might be important in the inflammatory process. To our knowledge the increase in ILA is a novel finding that may have new treatment implications. Published by Elsevier Inc. Interstitial cystitis patients ' use and rating of complementary and alternative medicine therapies. The purpose of this study was to describe the use of complementary and alternative medicine CAM therapies among interstitial cystitis IC patients , patients ' perception of CAM therapies' effectiveness, and the association of time since diagnosis with perceived effectiveness of these therapies.
Respondents indicated whether they received an IC diagnosis and how long ago, whether they tried CAM, and who recommended it. On a 5-point scale, respondents rated 49 therapies. For respondents confirming a diagnosis, we used a chi-square goodness-of-fit test to assess which therapies were rated positively or negatively by a majority of patients who tried them.
Using separate one-way analyses of variance, we assessed differences in mean perceived effectiveness among groups based on time since diagnosis and conducted post hoc tests, if necessary. Using chi-square tests, we explored the association of time since diagnosis with the use of CAM and the number of therapies tried. A total of 2, subjects responded to the survey; 1, confirmed an IC diagnosis.
Most Of those trying CAM, Of the therapies, 22 were rated positively and 20 negatively; 7 were inconclusive. Therapies patients perceived to be helpful included dietary management and pain management adjuncts such as physical therapy, heat and cold, meditation and relaxation, acupuncture, stress reduction, exercise, and sleep hygiene. Many therapies worked better for those diagnosed recently than for those diagnosed long before. Randomized, placebo-controlled studies are needed to demonstrate which therapies may indeed control IC symptoms and help send research in new and productive directions.
One hypothesis is that interstitial cystitis symptoms arise from increased bladder permeability to urine solutes. This study establishes the feasibility of using contrast enhanced magnetic resonance imaging to quantify bladder permeability in patients with interstitial cystitis. Permeability alterations in bladder urothelium were assessed by intravesical administration of the magnetic resonance imaging contrast agent Gd-DTPA Gd-diethylenetriaminepentaacetic acid in a small cohort of patients.
Magnetic resonance imaging signal intensity in patient and control bladders was compared regionally and for entire bladders. Data suggest that contrast enhanced magnetic resonance imaging provides an objective, quantifiable measurement. Alkalinized lidocaine and heparin provide immediate relief of pain and urgency in patients with interstitial cystitis. It has been reported in an open-label study that the combination of alkalinized lidocaine and heparin can immediately relieve the symptoms of urinary urgency, frequency, and pain associated with interstitial cystitis IC.
This combination has also been reported to relieve pain associated with sex in patients with IC. The aim of this study was to corroborate these findings in a multicenter setting. The study design was a multicenter prospective, double-blind, crossover, placebo-controlled trial. Each patient received drug and control, in random order, within 48 hours of enrolling in the study. The primary outcome measure was percent change in pain score point analog pain scale 12 hours after receiving the drug or control.
Secondary measures were the global assessment response GAR of symptoms and hour average urgency reduction determined from point urgency scales. Eighteen 18 patients completed the trial. The combination of alkalinized lidocaine and heparin provides up to 12 hours of relief from urgency and pain associated with IC. This combination provides significant immediate relief of symptoms for patients with IC.
tiosurrano.tk No clinical characteristic picture and impact of symptoms on quality of life QOL of interstitial cystitis IC patients in Taiwan had been reported. This paper is intended to provide preliminary descriptive results of IC research in Taiwan. Evaluation data included baseline demographic information, patient and family medical history, dietary effects, pregnancy data, sexual relationships with symptoms, and impact of symptoms on quality of life.
The main responsibility of the hospitals discussed was patient care and data collection. Taichung Hospital presents the results. Interstitial cystitis patients in Taiwan have lower economic status but lower impact on QOL than Western patients. However, the sexual-related pain and sleeping disorder were higher than previously thought and deserve our attention.
Accordingly, this research provides a foundation for further investigations of baseline associations and longitudinal trends. There were no significant differences between the groups in answers to the other five questions of the BBDQ. Further prospective studies are needed to further evaluate these novel findings.
The project is ongoing. One of the directions of alternative therapies is a traditional Chinese medicine using a special diet, various animal and plant-derived medicines, breathing exercises and acupuncture.
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The presented data indicate that these methods appear to be promising, since they are effective in a significant number of patients , lead to an improvement in their quality of life, are non-invasive and well tolerated. However, due to the lack of clinical studies, the efficacy of this treatment modalities needs to be confirmed. Urine samples were assayed for MIF by enzyme-linked immunosorbent assay. Healthcare resource utilization was evaluated in the one-year follow-up period as follows: number of outpatient visits and inpatient days, and the mean costs of outpatient and inpatient treatment.
We compared the rate of mental health disorders in male and female patients with pelvic pain and control subjects.